2 edition of Characterisation of the damage to the mitochondrial DNA (mtDNA) of cultured vascular endothelial cells induced by hyperglycaemia and various chemical agents found in the catalog.
Characterisation of the damage to the mitochondrial DNA (mtDNA) of cultured vascular endothelial cells induced by hyperglycaemia and various chemical agents
Nader David Egawhary
Thesis (Ph.D.) - University of Warwick, 1997.
|Statement||Nader David Egawhary.|
|The Physical Object|
|Number of Pages||220|
MITOCHONDRIAL DNA STRUCTURE AND FUNCTION mitochondria. ATA codes for methionine in mitochondria but isoleucine in the cytosol. Finally, AGA or AGG in mitochondria code for a stop codon instead of arginine (Table I) (Anderson et al., ). IIh Slructure of the Human mtDNA D-Loop Region. Mitochondrial DNA (mtDNA) and mitochondrial genes are more vulnerable than nuclear DNA and nuclear genes to damage caused by chemical toxicants (like pharmaceuticals and environmental pollutants) because mitochondrial genes “sit on a single circular chromosome (unlike the linear chromosomes of the nucleus) and are ‘naked’ – they’re.
If this mitochondrial DNA damage is not repaired, it can lead to disruption of the electron transport chain and increased generation of ROS, possibly resulting in vicious cycle of ROS production and mitochondrial DNA damage, leading to energy depletion and ultimately cell death (Harman, ; Miquel et al., ). Therefore suggesting that mitochondria must employ some form of repair or defence mechanism against such forms of deleterious by: 1. In partial fulfillment of the requirements for the Doctor of Philosophy degree in the Graduate School of Biomedical Sciences, Danielle Reid will present a research proposal seminar entitled, “Characterization of Mitochondrial DNA Damage in Complex Disease Using Two Different NGS Platforms” on Ma , at p.m. at https://unthsc.
Mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation. Oxidative phosphorylation is a process that uses oxygen and simple sugars to create adenosine triphosphate (ATP), the cell's main energy source. A study that focused on mitochondrial DNA (mtDNA) included 21 Veterans with Gulf War illness (GWI) and seven controls. In blood tests, researchers observed more lesions and more mitochondrial DNA—that is, extra copies of genes—in Veterans with Gulf War illness, relative to controls without the illness, suggesting excess DNA damage.
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Since mtDNA replication is dependent on transcription, mtDNA damage may alter mitochondrial gene expression at three levels: by causing DNA polymerase γ nucleotide incorporation errors leading to mutations, by interfering with the priming of mtDNA replication by the mitochondrial RNA polymerase, or by inducing transcriptional mutagenesis or premature transcript by: Koczor, C.
et al. Mitochondrial DNA damage initiates a cell cycle arrest by a Chk2-associated mechanism in mammalian cells. Biol. Chem.– Cited by: 5. Construction and Characterization of a Cell Line Deficient in Repair of Mitochondrial, but Not Nuclear, Oxidative DNA Damage Sugako Oka, Mizuki Ohno, Yusaku Nakabeppu Pages Characterisation of the damage to the mitochondrial DNA (mtDNA) of cultured vascular endothelial cells induced by hyperglycaemia and various chemical agents.
Thesis (Thesis) Find all citations by this author (default). The Biogenesis of Mitochondria: Transcriptional, Translational and Genetic Aspects covers the symposium, ""Biogenesis of Mitochondria"", held in Rosa Marina near Bari, Italy in June Organized into three parts, this book first discusses the mechanism, products, and role of mitochondrial DNA in mitochondrial transcription, including the.
It’s known that FQ’s indeed do direct genomic damage to mitochondrial DNA, as evidenced by mitochondrial DNA breaks from FQ treated cells. On the other hand, it’s my opinion that mitochondria are as much or more vulnerable to FQ’s due to indirect damage as well.
The thing to know about mitochondria. However, the hypothesis that turnover (degradation) of damaged mtDNA can be a mechanism used by mitochondria to deal with either excessive damage, or damage that can not be repaired did not take hold in part due to the lack of direct experimental evidence supporting it and in part due to discovery of mitochondrial BER (Pettepher et al., ), which shifted attention from unrepairable lesions to Cited by: 3.
The circular mitochondrial genome (mitogenome) of Phymatostetha huangshanensis is 17, bp long. It contains the typical set of 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), two ribosomal RNA genes (rRNAs), and a large control by: 8.
Mormons and Mitochondrial DNA by Chad Ressler In August Simon Southerton released a book entitled Losing a Lost Tribe: Native Americans, DNA, and the Mormon Church. 1 Southerton concludes from studies of mitochondrial DNA of Native Americans that the Mormon claim of their descent from Israeli immigrants is unsupported by DNA evidence.
consequences of mitochondrial DNA (mtDNA) damage based on the analysis of v ariabil- ity of mitochondrial genome. The paper is devoted to identi cation of genetic markers.
From the reviews: "The study of the variation in mitochondrial DNA has significantly deepened our knowledge about human dispersal. The book is clearly written and benefits from the true experts in the field. it provides a strong and helpful basis and serves as a well-selected summary. everybody involved in mtDNA research is sooner or later advised to have a look at it."Format: Hardcover.
Some forms of mitochondrial DNA damage can apparently trigger mitochondrial DNA destruction, either via direct degradation or through specific forms of autophagy, such as mitophagy.
However, accumulation of certain types of mitochondrial damage, in the absence of DNA ligase III (Lig3) or exonuclease G (EXOG), enzymes required for repair, can directly trigger cell by: DNA serves as a lineal history, a family album, a passport that bears the marks of both origin and journey.
Mitochondrial DNA (mtDNA) is inherited only from the mother. All cells have DNA so it shouldn't be surprising that mitochondria also have some DNA still if this theory is true.
Biologists do think that some of the mitochondrial DNA still functions, but many of its functions have been lost due to the lack of selective pressure (if it is not needed because of redundencies in the nuclear DNA from the larger.
In Mitochondrial DNA: Methods and Protocols, Second Edition, specialists from eight countries share their expertise, providing detailed protocols for studying many aspects of mtDNA.
The volume is divided into three sections, which cover the transduction of information from mtDNA to functionally active respiratory complexes, mitochondrial. Mitochondrial DNA control region as a tool for species identification and distinction between wolves and dogs from Croatia Article (PDF Available) in Veterinarski Arhiv (81) March.
Characterisation of the damage to the mitochondrial DNA (mtDNA) of cultured vascular endothelial cells induced by hyperglycaemia and various chemical agents.
Author: Egawhary, Nader David. ISNI: Awarding Body: University of Warwick. However, with regard to DNA damage, few studies have looked into the effect of curcumin on mitochondrial DNA (mtDNA). The kb mitochondrial genome has been fully sequenced and encodes for only 13 proteins involved in the electron transport chain of oxidative phosphorylation (Linnane et al., ).Cited by: Key To Aging: Mitochondrial DNA.
"It seems to be a universal phenomenon in mammals that you have this damage to mitochondrial DNA as you get older," said the study's senior author, Nils-Goran. mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA).
Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-loop) and in particular in a polycytidine stretch (C-tract) termed DCited by:. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial.
As noted above, mitochondrial damage, oxidative stress, and the vicious cycle between them has been linked to every chronic disease that plagues people – diabetes, Alzheimer’s, autism, etc.
Fluoroquinolone antibiotics damage mitochondria and cause an increase in ROS/oxidative stress. Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the DNA (hereditary material that is passed from parent to child) is packaged within the nucleus of each cell (known as nuclear DNA).
However, mitochondria (the structures in each cell that produce energy) contain a small .